It can be tough watching your dog slow down as they get older and find simple activities, such as jumping on the sofa or running down the stairs, harder.
Best Dog Hip & Joint Supplements Quick Verdict |
After testing all six supplements with Skye and Copper, we found that powder formats came out on top for us. Powders bypass the extra binders and fillers needed for soft chews, offer better absorption, and were far easier to sprinkle onto Skye’s raw breakfast without any picky eating battles.Â
Dog Is Human MultiFlex is our #1 overall recommendation for its high-potency, vet-formulated blend, human-grade standards, and mess-free stick packs (which made splitting a single daily pack between two 15-lb Klee Kai surprisingly cost-effective). If your dog prefers a soft chew, PetLab Co. Joint Care was Skye and Copper's favorite for taste and soft texture. Bernie's Best and Zesty Paws offer the best daily value for budget-conscious owners of smaller dogs.  |
Skye turned nine this summer, and we’ve noticed a slight slowing down, whether that’s playing a little less with Copper or a little less spring in her step.
With that in mind, we started researching the best hip and joint supplements to take a more proactive approach as our Alaskan Klee Kai get older.
Finding a quality supplement can be tricky with some brands hiding behind confusing labels, weak dosages and marketing buzz.
As someone who is helping his wife build a supplement brand for women, I’ve come to understand the importance of third-party testing, dosages and transparency.
In this guide to the best hip and joint supplements, we’ve rated six potential options, from soft chews to clean human-grade powders, comparing active ingredients, daily costs and ingredient transparency.
At a Glance: Top Picks for 2026
| Category | Product | Form | Key ingredients | Third-party tested | GMP certified facility | Price |
|---|---|---|---|---|---|---|
| Best Powder | Dog Is Human | Powder (stick packs) | Glucosamine, MSM, UC-II Collagen, Boswellia | Yes | Yes | $58 |
| Best Natural | Native Pet | Powder (tin) | Green-Lipped Mussel, UC-II, myHMB, Whey | Yes | Yes | $24.99 |
| Best Multi Mechanism | Bernie's | Chew | UC-II Collagen, Astaxanthin, Boswellia, Omega-3s | Yes | Yes | $29.99 |
| Best High Potency | Wuffes | Chew | Glucosamine (1,250mg), MSM, Hyaluronic Acid | Yes | Yes | $49.95 |
| Best Targeted | PetLabCo | Chew | Glucosamine, Green Lipped Mussel, Turmeric | Yes | Yes | $38.69 |
| Best Daily Value | Zesty Paws | Chew | Glucosamine, OptiMSM®, Chondroitin | Yes | Yes | $24.97 |
How We Evaluated These Supplements

We paid close attention to a few factors when assessing the best hip and joint supplements, and we tested them on Copper and Skye.
As we have formulated a supplement (albeit for human consumption), we understand the process behind formulating and manufacturing supplements.
We evaluated the active ingredients for both potency and quality. There are active ingredients such as glucosamine and green-lipped mussel we’d expect to see.
Another aspect is the brains behind the formulation. We’d expect to see a veterinarian, ideally a board-certified veterinary nutritionist, involved in the supplement’s formulation.
The facility matters, too. We looked for supplements manufactured in a facility that follows good manufacturing practices (GMP) and is third-party tested, with the NASC seal.
Ultimately, Copper and Skye had to like the hip and joint supplement; otherwise, it’s a pointless investment. So we watched their reaction and eating patterns.
Dog Is Human MultiFlex — Best Powder / Human-Grade

Why It Made The Cut
Dog Is Human uses human-grade ingredients to create their Multiflex hip and joint supplement. They use powder in stick packs; you get 30 in a box. We like that Copper and Skye receive maximum, precise dosing in a more bioavailable format without chew binders.
You can read my dedicated review of Dog Is Human Multiflex
Multiflex was appealing because it’s made from six clinically studied ingredients. I was drawn to the supplement because of its 4-in-1 approach. Dog Is Human targets cartilage cushion support, inflammatory response support, balanced immune health, and connective tissue support. They relied on the expertise of Dr Michael Chae DVM to formulate Multiflex. In my research, I discovered their supplement is made in a GMP facility and undergoes third-party testing.
Pros
- 100% human-grade with zero artificial ingredients, binders or fillers
- Features a patented ingredient UC-II Collagen, alongside Glucosamine/MSM
- Stick packs to ensure accurate and potent daily dosage
- Powder form easy to add to Copper and Skye’s raw food
Cons
- Expensive (30 stick packs, although I had 60 doses as Copper and Skye shared daily stick pack)
- If your dog doesn’t like powder or you don’t want to mix it in their food, you may prefer the chew format
Verdict
Multiflex is an investment in your dog’s health at $58 for a 30-day supply. As Copper and Skye are 15lbs, I was able to use one stick pack for both Klee Kai dogs. It works out cheaper if you’ve got smaller dogs. It was a hit with my dogs because it was easy to sprinkle over their raw dog food. They ate it every day at breakfast time, and I don’t think they even noticed it was there.
Native Pet Hip and Joint — Best Natural Whole-Food

Why It Made The Cut
Native Pet has clear packaging, like Dog Is Human, so it doesn’t feel overwhelming when you’re holding the tin in hand. It has a 3-in-1 approach to mobility care, targeting joints, muscles and a healthy inflammatory response. It comes in powder format with 30 scoops contained inside. I was drawn to their approach because Native Pet is minimally processed with a clean ingredient label.
Does your dog have smelly glands?
You can read my review of Wondergland.
They use nine ingredients in the formulation of their Hip + Joint Advanced Care supplement. We were drawn to Native Pet because they use clean ingredients in their vet-formulated supplement. Board-certified veterinary nutritionist Dr Dan Su is behind the formulation. I also noted that it’s made in a NASC-audited GMF facility and undergoes third-party testing.
Pros
- Clean ingredients and minimally processed
- Highly palatable flavor for picky dogs
- Powder format to easily add in at mealtime
- Manufactured in a GMF facility and undergoes third-party testing
Cons
- Pricey but not the most expensive option
- Doesn’t contain Glucosamine (uses Green-Lipped Mussel)
My verdict

Native Pet Hip And Joint Advanced Care is another good option, especially if you prefer a powder format, as I do. The price starts at $39.99, but you can get it for less by subscribing. It was a hit with Copper and Skye because I could easily use the included scooper to sprinkle it over their breakfast.
Bernie’s Best Healthy Hips — Best Multi-Mechanism

Why It Made The Cut
I was drawn to Bernie’s Healthy Hips because they’ve got 16 active ingredients. Their hip and joint formula is designed to support healthy mobility and comfort. There’s a lot going on with the label, but there are some encouraging signs, such as their supplement being rooted in science. Each plastic tub contains 90 chews.
It’s great that Bernie’s uses 16 active ingredients, but the dosing is equally as important. They’ve got a slightly different approach to some other supplement companies, with a stronger botanical and antioxidant focus. Bernie’s Healthy Hips targets healthy joints through modern biological pathways. For instance, to examine just one of the active ingredients, they use Green-Lipped mussel at 50mg, whereas Native Pet uses 300mg.
Pros
- Combines potent natural anti-inflammatories
- Provides triple-source Omega-3s
- Chew format may suit some dogs better
- Excellent value for money
- Made in GMP certified facility
Cons
- Doesn’t contain Glucosamine and uses a lesser dose of Green-Lipped Mussel
- 16 active ingredients
- Pet owners need to check for allergies to any of 16 ingredients
- Use pork if your dog has any pork allergies
My Verdict

I gave Bernie’s Best Healthy Hips a try. I was impressed with the value on offer, with a tub of 90 chews costing $29.99. That’s a 45-day supply for Copper and Skye at almost half the price of Dog Is Human. Skye was a little fussy with the chew after a week. She preferred the powder format, while I liked the less is more approach of the aforementioned brands.
Wuffes Hip and Joint — Best High-Potency Traditional

Why It Made The Cut
Wuffes are well-established dog supplement company, and their hip and joint supplement features the common active ingredients you’d expect to find in such a product. Wuffes relies on the popular trio of Glucosamine, Chondroitin, and MSM. There are 60 chews per jar.
The thing that really stood out about Wuffes is the dosing – you can’t miss it on the front of the jar. I like that Wuffes offers different dosing for dogs of all sizes. So you can select a small or medium breed, or a large or extra-large breed. None of the other brands offer this. When we look at the triad of ingredients mentioned above, Wuffes has formulated each chew to contain 400 mg of glucosamine, 200 mg of MSM, and 50 mg of chondroitin for their small- and medium-breed versions.
Pros
- Separate formulations for different sizes and breeds
- Inclusion of hyaluronic acid to keep cartilage lubricated during daily exercise
- Manufactured in cGMP compliant facility
- Third-party testing
Cons
- Chews were slightly denser than rivals
- Dog Is Human had higher dosing for three key ingredients
- Use pork if your dog has any pork allergies
My verdict

I appreciated that Wuffes offers different formulations for different breeds and sizes. You can even purchase small/medium and medium/large as a two-pack on Amazon. That’s handy if you have big and small dogs. It starts at $38.95 for 60 chews for Copper and Skye’s size. Skye was a little hit-and-miss with the chews, perhaps because they were a little dense.
PetLabCo Joint Care — Best Daily Value & Availability

Why It Made The Cut
PetLabCo is a brand I’ve been familiar with for a few years, having previously tested some of their supplements. Their supplement comes in a chew format, with 30 inclided in a jar. Their chews are shaped like a bone, which is a novelty. There’s a marine focus with 600 mg Glucosamine (shellfish), 100mg Green-Lipped Mussel and 72mg Total Omega-3 fatty acids.
What stood out to me in their formulation is the inclusion of Calcium Fructoborate. I didn’t notice this plant-based mineral complex in any of their supplement featured in this guide. It helps support joint comfort and flexibility.
Pros
- Inclusion of calcium fructoborate
- Chew format
- Pork or salmon flavor
- Value pack option
Cons
- Only 30 chews per jar
- Best price requires signing up for a monthly auto-ship subscription
- Less glucosamine compared to Dog Is Human
My Verdict

Of all the chews featured, this was Copper and Skye’s favorite. They were fans of the pork and salmon. It wasn’t as dry as some of the others, with a softer texture. It’s reasonably priced at $38.69, but you can get it for $30.95 if you subscribe and save.
Zesty Paws Hip and Joint

Why It Made The Cut
I decided to include Zesty Paws because they’re one of the more competitively priced at $32.97 for 90 chews. They offer two flavors: chicken and duck. Zesty Paws ticks all the boxes by being made in a cGMP-compliant facility and undergoing third-party testing.
They use some commonly found hip and joint active ingredients, such as Glucosamine HCl (450mg) and Chondroitin Sulfate (125mg). I noticed that Zesty Paws uses OptiMSM®, a patented, highly purified form of MSM. However, they don’t specify the dosages of each active ingredient on the label. Instead, they describe it as their proprietary blend.
Pros
- Excellent value for small and medium dogs at $32.97 for 90 chews
- Uses highly purified and easily absorbed OptiMSM
- Two flavors
- Average score of 4.4 stars based on 8,000+ Amazon reviews
Cons
- Larger dogs may require two or three chews a day to reduce the value on offer
- Mixed customer reviews when you Google their supplement
- Recalls on some products in 2025 but not this specific product
*Note on Safety: While a localized batch of Zesty Paws Hemp Elements chews was voluntarily recalled for Salmonella testing, the core Mobility Hip & Joint Bites line remained unaffected, and the brand maintains its NASC Quality Seal standards
My Verdict

I’ve included Zesty Paws in this guide because of the value they offer to pet owners with small and medium dogs. My cost per chew is 36 cents (based on $32.97 for a 90-count tub). That’s great value. However, it does lose its value if you’ve got a larger dog. The treat’s texture was a little dry, so it wasn’t my Alaskan Klee Kai’s favorite.
Price Per Serving Table
| Product | Retail Price/Count | Daily Cost (Small Dog: ~15 lbs) | Daily Cost (Medium Dog: ~40 lbs) | Daily Cost (Large Dog: ~70 lbs) |
|---|---|---|---|---|
| Dog Is Human | $58.00 / 30 packs | $0.96 (1/2 pack) | $1.93 (1 pack) | $1.93 (1 pack) |
| Native Pet | $39.99 / 30 scoops | $0.66 (1/2 scoop) | $2.00 (1.5 scoops) | $3.99 (3 scoops) |
| Bernie's | $29.99 / 90 chews | $0.33 (1 chew) | $0.66 (2 chews) | $1.00 (3 chews) |
| Wuffes | $38.95 / 60 chews | $0.65 (1 chew) | $1.30 (2 chews) | $1.95 (3 chews) |
| PetLabCo | $38.69 / 30 chews | $1.29 (1 chew) | $2.58 (2 chews) | $3.87 (3 chews) |
| Zesty Paws | $32.97 / 90 chews | $0.36 (1 chew) | $0.72 (2 chews) | $1.09 (3 chews) |
Frequently Asked Questions

I started introducing supplements to my dogs around the 6-month mark after speaking to my vet. I added a hip-and-joint supplement in the past few years because Copper and Skye are eight and nine, respectively, and I want to take a proactive approach to their health.
As a supplement founder, I’ve come to understand consistency is key. You won’t see instant results. Instead, you may see some after a month, but most likely after three months of consistent use.
This depends on a couple of things. Powder is more bioavailable and more easily absorbed than chews. You won’t find any binding ingredients in powder, either. But you know your dog best. Every dog is different, and some may prefer a treat-like chew. My dogs prefer powder sprinkled on their food.
You can spot some early signs, such as reluctance to jump on furniture, rising more slowly after napping or sleeping, sighing when they lay down, slower on walks, and less enthusiasm for games such as chase and fetch.
We recommend speaking with your vet before adding a new supplement to your dog’s diet.
If you want dog food with supplements included,
you can check out my Get Joy review.
Final Verdict

We’ve broken down six potential options for pet owners looking to add a mobility supplement to their dog’s daily diet.
I’ve tested all six options, but my favorites remain the powder options: Dog Is Human and Native Pet.
Not only does my picky Klee Kai Skye prefer powder that’s sprinkled on top of her raw dog food, but I also love that it’s better absorbed.
You can read my review of Dog Is Human multivitamin
While all six supplements have their pros and cons, I believe Dog Is Human’s formula stood out with high dosages of key active ingredients.
I appreciated the convenience of stick packs, which created less mess, and I could split one between my two dogs daily.
My top recommendation would be Dog Is Human’s multiflex, which I’ve tested on my Klee Kai for the past couple of months.



